Lazio begin their Champions League campaign against Diego Simeone’s Atletico Madrid with Ciro Immobile, Daichi Kamada and Luis Alberto against Antoine Griezmann and Alvaro Morata.
It kicks off at the Stadio Olimpico at 20.00 UK time (19.00 GMT).
The Aquile return to the Champions League after finishing second in Serie A last season, although they have had a shaky start to the current campaign, losing three out of four matches, winning only away to Napoli.
There is a full squad to choose from, as Felipe Anderson and Mattia Zaccagni flank Immobile.
Matteo Guendouzi was expected to get his first start, instead it is Matias Vecino who comes in for Cataldi.
Atletico Madrid have numerous absentees, the most recent Thomas Lemar with a lacerated Achilles tendon out for several months.
He joins Rodrigo De Paul, Jose Maria Gimenez, Caglar Soyuncu, Koke, Mephis Depay and Reinildo on the treatment table.
There are quite a few familiar faces to Serie A, including ex-Udinese right-back Nahuel Molina, former Juventus striker Morata, one-time Fiorentina defender Stefan Savic and of course coach Simeone, who was a player for Pisa, Inter and then from 1999 to 2003 here at Lazio.
Atleti were unbeaten this season until Saturday’s 3-0 defeat to Valencia.
Lazio: Provedel; Marusic, Patric, Romagnoli, Pellegrini; Kamada, Vecino, Luis Alberto; Felipe Anderson, Immobile, Zaccagni
Lazio bench: Sepe, Renzetti, Guendouzi, Pedro, Casale, Isaksen, Castellanos, Hysaj, Lazzari, Cataldi, Mario Gila, Rovella
Atletico Madrid: Oblak; Molina, Savic, Lino, Hermoso; Barrios, Witsel, Saul Niguez, Marcos Llorente; Griezmann, Morata
Atletico Madrid bench: Grbic, Antonio Gomis, Gimenez, Azpilicueta, Correa, Galan, Riquelme, Kostis, El Jebari, Calatrava, Guerrero
Ref: Vincic (SVN)